Catalytic method enables difunctionalization of oxindoles with heteronucleophiles, suggesting broader applications.
Herein, we report a catalytic, redox-neutral method for the difunctionalization of oxindoles using ketimines derived from anilines and heteronucleophiles. The reaction proceeds through a dearomatization-aromatization strategy via a tetra-substituted alkene intermediate stabilized by extended resonance, facilitating the selective formation of 3,3-disubstituted oxindoles with a wide chemical space in good-to-high yields.
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Jha et al. (2025) studied this question.
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