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September 10, 2025Biochemical GeneticsOpen Access

MRPL15 as a Key Gene in the Malignant Proliferation of LUAD

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Authors

ZWZhi WangYQYing QianXLXin Lai

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Overview

Observational analysis showed MRPL15 promotes proliferation in lung adenocarcinoma, indicating its potential as a therapeutic target.

Key Points

  • MRPL15 was significantly overexpressed in lung adenocarcinoma tissues compared to adjacent tissues.
  • The positive correlation between MRPL15 and MKI67 highlights its role in tumor progression.
  • Overexpression of MRPL15 advanced LUAD cell proliferation, while its knockdown restricted growth.
  • MRPL15 may be a potential biomarker and therapeutic target for treating lung adenocarcinoma.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1a13354b1d3bfb60dc80ehttps://doi.org/10.1007/s10528-025-11204-1
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Also Consider

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  1. 1MRPL17 is a critical regulator of mitochondrial function and a novel therapeutic target in non-small cell lung cancer2025 · 1 citations
  2. 2RPL22L1 is a novel biomarker for prognosis and immune infiltration in lung adenocarcinoma, promoting the growth and metastasis of LUAD cells by inhibiting the MDM2/P53 signaling pathway2024 · 3 citations
  3. 3A80-2-05 The Prognostic Utility of Mitochondrial Ribosomal Protein L47 (MRPL47) Expression in Lung Adenocarcinoma: Implications for Immune Modulation and Therapeutic Resistance to Erlotinib2026
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  5. 5MRPL47 deficiency drives mitochondrial dysfunction via ROS-p38-p21 signaling in non-small cell lung cancer2025 · 1 citations