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May 20, 2026American Journal of Respiratory and Critical Care Medicine

A80-2-05 The Prognostic Utility of Mitochondrial Ribosomal Protein L47 (MRPL47) Expression in Lung Adenocarcinoma: Implications for Immune Modulation and Therapeutic Resistance to Erlotinib

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Authors

MQM H QasmiehJordan University of Science and TechnologyASA H Al SharieSoutheast Health DistrictJAJ AlseidiSaint Michael's Medical Center

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Implication

Randomized trial investigates MRPL47's role in prognosis and response to erlotinib in lung adenocarcinoma, suggesting its potential as a biomarker.

Key Points

  • This study examines the prognostic significance of MRPL47 expression in lung adenocarcinoma and its relationship with immune modulation and resistance to erlotinib.
  • Accessed TCGA-LUAD cohort (n = 576) via UCSC Xena browser for clinical data and MRPL47 expression profiles.
  • Utilized Kaplan-Meier estimator and Cox regression analyses to evaluate overall survival.
  • Assessed MRPL47's impact on tumor immune microenvironment and response to erlotinib using TIMER 2.0 and CPADS.
  • Upregulation of MRPL47 linked to poor prognosis with hazard ratio of 1.546 (95% CI: 1.120-2.133, P = .008).
  • MRPL47 expression correlated with myeloid-derived suppressor cells (ρ = 0.582, P < .001).
  • Low MRPL47 expression associated with better response to erlotinib, evidenced by significantly lower IC50 (P = .0034).

Cite This Study

Qasmieh et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f19f03e14405aa9a4d8https://doi.org/10.1093/ajrccm/aamag162.3661
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MRPL47 deficiency drives mitochondrial dysfunction via ROS-p38-p21 signaling in non-small cell lung cancer2025 · 2 citations
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  3. 3Identification of candidate biomarker MRPL23 and its prognostic potential in non-small cell lung cancer with emphasis on the squamous cell carcinoma subtype2026
  4. 4MRPL27 as a new prognostic biomarker involved in immune cell infiltration and hepatocellular carcinoma progression2024
  5. 5MRPL23 Overexpression Predicts Poor Survival and Is Associated with Mitochondrial Respiratory Signatures in Glioblastoma2026