What question did this study set out to answer?

This research aims to assess the prognostic significance of MRPL23 expression in glioblastoma and its relationship to survival outcomes and mitochondrial function.

July 12, 2026CancersOpen Access

MRPL23 Overexpression Predicts Poor Survival and Is Associated with Mitochondrial Respiratory Signatures in Glioblastoma

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Authors

JDJustyna DurślewiczBydgoszcz University of Science and Technology MZMarek ZdrenkaBydgoszcz University of Science and Technology ŁSŁukasz SzylbergJanelia Research Campus

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Implication

Randomized trial evaluates MRPL23 expression and its impact on survival in glioblastoma, suggesting its role as a biomarker.

Key Points

This research aims to assess the prognostic significance of MRPL23 expression in glioblastoma and its relationship to survival outcomes and mitochondrial function.
MRPL23 protein expression assessed by immunohistochemistry in tissue microarrays of 89 glioblastoma patients and 36 adjacent non-tumorous samples.
Survival analyses utilized Kaplan–Meier estimates and Cox proportional hazards models.
In silico validation was performed using transcriptomic and proteomic data from 296 IDH-wildtype glioblastomas from The Cancer Genome Atlas.
MRPL23 expression significantly upregulated in glioblastoma compared to non-tumorous tissue (p < 0.001).
High MRPL23 expression linked to shorter overall survival (median 13.5 vs. 21 months, p = 0.013).
Low MRPL23 levels in TCGA cohort associated with better overall and progression-free survival.

Cite This Study

Durślewicz et al. (2026) studied this question.

synapsesocial.com/papers/6a532f464f7abc118aded02f https://doi.org/10.3390/cancers18142226

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MRPL23 Overexpression Predicts Poor Survival and Is Associated with Mitochondrial Respiratory Signatures in Glioblastoma

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Key Points

Cite This Study

MRPL23 Overexpression Predicts Poor Survival and Is Associated with Mitochondrial Respiratory Signatures in Glioblastoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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