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September 10, 2025Frontiers in ImmunologyOpen Access

Targeting myeloid cells to improve cancer immune therapy

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Authors

HCHui ChenUniversity of Hong KongZXZihan XuJiangnan UniversityJVJudith A. VarnerUniversity of San Diego

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Overview

This review discusses myeloid cell functions in the tumor microenvironment and highlights therapeutic strategies targeting immune checkpoints.

Key Points

  • Targeting myeloid cells enhances anti-tumor immunity by overcoming immunosuppression.
  • Key immune checkpoints identified include Trem2, LILRBs, and VISTA, influencing therapy effectiveness.
  • Understanding myeloid cell biology provides new avenues for disrupting immunosuppressive pathways.
  • Challenges remain in translating these myeloid targeting strategies into effective clinical applications.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd418https://doi.org/10.3389/fimmu.2025.1623436
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Also Consider

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  1. 1Potential therapeutic targets in myeloid cell therapy for overcoming chemoresistance and immune suppression in gastrointestinal tumors2024 · 5 citations
  2. 2Targeting Myeloid Cells for Cancer Immunotherapy2025
  3. 3Inflammation and Myeloid Cells in Cancer Progression and Metastasis2022 · 37 citations
  4. 4Immune Cells in the Tumor Microenvironment: Mechanisms of Immune Resistance and Therapeutic Advances2026
  5. 5Targeting polymorphonuclear myeloid‐derived suppressor cells in the immunosuppressive tumor microenvironment for cancer immunotherapy2024