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September 10, 2025New medicine.

Immunomodulatory roles of tumor-derived extracellular vesicles and their therapeutic implications in breast cancer

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Overview

Observational analysis reveals tumor-derived extracellular vesicles impact immune responses in breast cancer, suggesting diagnostic and therapeutic potentials.

Key Points

  • Tumor-derived extracellular vesicles impair immune responses, contributing to immunosuppression in breast cancer.
  • These vesicles transport immunosuppressive factors like PD-L1 and TGF-β that hinder immune cell functions.
  • Novel therapeutic strategies targeting extracellular vesicle cargo show promise to enhance immunotherapy efficacy.
  • Challenges in TEV heterogeneity and clinical translation necessitate multidisciplinary research approaches.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68c1a27254b1d3bfb60ddc13https://doi.org/10.61958/nmhs2499
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Also Consider

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  1. 1CCAAT enhancer binding protein delta activates vesicle associated membrane protein 3 transcription to enhance chemoresistance and extracellular PD-L1 expression in triple-negative breast cancer2024 · 12 citations
  2. 2Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer2022 · 403 citations
  3. 3Breast cancer: pathogenesis and treatments2025 · 908 citations
  4. 4Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)2010 · 460 citations
  5. 5Plasma exosome microRNAs are indicative of breast cancer2016 · 626 citations