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September 10, 2025Avicenna journal of dental researchOpen Access

Nanofibers Loaded With Vancomycin for the Treatment of Periodontal Infections: Synthesis, Characterization, Efficacy, and Safety Tests

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Authors

MBMahshad Noori BarkestaniHamedan University of Medical SciencesHMHazhir MaslahatyHamedan University of Medical SciencesNANegar Sedghi AminabadTabriz University of Medical Sciences

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Overview

Electrospinning creates vancomycin-loaded nanofibers, showing strong antibacterial properties and biocompatibility.

Key Points

  • Vancomycin-loaded nanofibers effectively killed pathogenic bacteria and stimulated cell growth.
  • The drug release from nanofibers reached about 80% within 24 hours, indicating sustained release.
  • Electrospinning produced uniform, nanosized fibers with high drug entrapment efficiency and biocompatibility.
  • Raising vancomycin concentrations improved swelling properties but reduced the tensile strength of nanofibers.

Cite This Study

Barkestani et al. (2025) studied this question.

synapsesocial.com/papers/68c1a27254b1d3bfb60ddce3https://doi.org/10.34172/ajdr.1969
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 13D Nanofibrous Scaffolds for Encapsulation-Controlled Vancomycin Delivery: Antibacterial Performance and Cytocompatibility2025
  2. 2Vancomycin‐Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds2025
  3. 3Fabrication and evaluation of a bi-layered electrospun polyacrylonitrile/polycaprolactone-chitosan/gelatin/polyethylene oxide nanofibers containing antibiotics and nanoparticles: antibacterial and antibiofilm activity2026
  4. 4Antioxidant/Antibacterial Nanofibers Loaded with Liposome-Encapsulated Proanthocyanidin Complexes: Machine Learning-Optimized Liposome Incorporated in Nanofibers Promotes Antibiotic-Free Wound Healing2026
  5. 5Antibiotic Delivery via a Chitosan-Based Nanofibrous Coating of Prosthetic Grafts for Treatment of Vascular Graft Infections2024