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July 8, 2026Scientific ReportsOpen Access

Fabrication and evaluation of a bi-layered electrospun polyacrylonitrile/polycaprolactone-chitosan/gelatin/polyethylene oxide nanofibers containing antibiotics and nanoparticles: antibacterial and antibiofilm activity

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Authors

RSRaha Zare ShahrakiLSLeili ShokoohizadehMAMohammad Hossein Armand

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Overview

Randomized trial evaluates antibacterial effectiveness of antibiotic-loaded nanofibers against MRSA and P. aeruginosa, suggesting their potential for wound healing.

Key Points

  • The aim is to develop and evaluate electrospun nanofibers containing antibiotics and nanoparticles for their antibacterial properties.
  • Fabrication of nanofiber scaffolds from PCL/PAN and Cs/Gel/PEO with antibiotic and nanoparticle incorporation.
  • Characterization of surface properties, antioxidant activity, and biocompatibility via various assays.
  • Antimicrobial tests conducted using disk diffusion methods against MRSA and P. aeruginosa, alongside biofilm inhibition assessments.
  • Cip-BG-Cs/Gel/PEO and bilayer scaffolds inhibited one-day biofilm formation of both bacteria compared to control.
  • Van-Ag-PAN/PCL, Cip-BG-Cs/Gel/PEO, and bilayer scaffolds achieved 66.3%, 68%, and 69.3% eradication of MRSA biofilms, respectively.
  • No cytotoxicity observed on L929 fibroblast cells; scaffolds demonstrated high antioxidant activity without inducing hemolysis.

Cite This Study

Shahraki et al. (2026) studied this question.

synapsesocial.com/papers/6a4de8ebd2ea289ef628371ahttps://doi.org/10.1038/s41598-026-60945-5
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