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June 13, 2026PharmaceuticsOpen Access

Advanced Antibacterial Nanocomposite Fibers for Biomedical Applications

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Authors

FAFrancisca AcevedoMAManuel AzócarESEulàlia Sans-Serramitjana

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Overview

Randomized trial develops antibacterial nanofibers, revealing enhanced efficacy against wound infections, suggesting a new treatment approach.

Key Points

  • This study aims to develop silver nanoparticles (AgNPs) with improved antimicrobial properties and evaluate their integration into nanofibers for wound care.
  • Synthesis of four AgNP formulations using chemical reduction with different stabilizers.
  • Physicochemical characterization including surface plasmon resonance and zeta potential measurements.
  • Assessment of antimicrobial activity through MIC and bactericidal assays against various bacterial and fungal strains.
  • Diclofenac-stabilized AgNPs exhibited the highest antimicrobial activity (MIC 18.8 mg/L against Staphylococcus aureus, 4.7 mg/L against Candida albicans).
  • HET-CAM assays showed negligible irritation at concentrations up to 75 mg/L.
  • Electrospun nanofibers with dc-AgNPs achieved a 2.6 log reduction in Streptococcus mutans and moderate log reductions against other pathogens.

Cite This Study

Acevedo et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf4aefaef96ed7f056d91https://doi.org/10.3390/pharmaceutics18060711
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrospun PVA/PEO/β-CD nanofiber composites incorporating chemically and biologically synthesized silver nanoparticles for enhanced antimicrobial activity2026
  2. 2Fabrication and evaluation of a bi-layered electrospun polyacrylonitrile/polycaprolactone-chitosan/gelatin/polyethylene oxide nanofibers containing antibiotics and nanoparticles: antibacterial and antibiofilm activity2026
  3. 3AgNPs–Cellulose Nanofiber/Polyacrylamide Hydrogels as an Antibacterial Platform for Soft Tissue2026
  4. 4Development of cross‐linked polyvinyl alcohol/sodium caseinate/silver nanoparticle electrospun mats for antibacterial wound dressing2024 · 7 citations
  5. 5Conjugated Polymer/Silver Nanoparticle Composites with Enhanced Electronic and Antimicrobial Properties for Sensing and Wound-Healing Applications2025