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September 10, 2025Advances in Clinical and Experimental MedicineOpen Access

MALAT1 modulates granulosa cells ferroptosis and apoptosis through PAK2 upregulation in polycystic ovary syndrome

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Authors

YYYun YangDLDan LiLSLu Sun

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Overview

Observational analysis reveals MALAT1 affects apoptosis and ferroptosis in granulosa cells, suggesting new therapeutic targets in PCOS.

Key Points

  • MALAT1 downregulation decreased cell viability and increased apoptosis in granulosa cells.
  • Inhibition of miR-155-5p reversed the effects of MALAT1 knockdown, indicating its regulatory role.
  • Bioinformatic predictions and dual luciferase assays demonstrated interaction between MALAT1 and PAK2.
  • Study findings establish the potential of MALAT1 in regulating ferroptosis and apoptosis related to PCOS.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c1a40954b1d3bfb60de60chttps://doi.org/10.17219/acem/202385
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MALAT1 expression in granulosa cells in PCOS patients with different phenotypes2024 · 1 citations
  2. 2Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS2022 · 34 citations
  3. 3Differential expression of microRNA-3127-5p and its molecular mechanisms in polycystic ovary syndrome2025 · 1 citations
  4. 4PTEN regulation by miR-486-5p contributes to the amelioration of polycystic ovary syndrome2025
  5. 5MALAT1 promotes acetaminophen-induced hepatocyte pyroptosis by stabilizing Rac1 through its interaction with MTDH and the hepatoprotective role of muniziqi saifula2026 · 1 citations