Why the study?
Whether long noncoding RNA is involved in anti-Mullerian hormone's role in follicular development in polycystic ovary syndrome is unknown.
Does lncRNA MALAT1 expression affect granulosa cell proliferation and predict pregnancy outcomes in patients with PCOS?
Population
Ovarian granulosa cells from women with and without PCOS, and KGN cells in vitro
Comparison
Women with PCOS vs without PCOS, and MALAT1 knockdown vs control
Design
In vitro laboratory and translational cohort study
Key result
Upregulated lncRNA MALAT1 in granulosa cells of patients with PCOS predicted positive clinical pregnancy outcomes with an area under the curve of 0.771.
Authors
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AMH upregulates MALAT1 to inhibit granulosa cell proliferation in PCOS; leaves open its role as biomarker or therapeutic target.
Case-Control (n=133)
No
Does lncRNA MALAT1 expression affect granulosa cell proliferation and predict pregnancy outcomes in patients with PCOS?
Effect estimate: AUC 0.771 (95% CI 0.617-0.925)
p-value: p=0.007
lncRNA MALAT1 is upregulated in PCOS, inhibits granulosa cell proliferation, and may serve as a predictor for clinical pregnancy outcomes.
Tu et al. (2022) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=133). lncRNA MALAT1 expression vs. Controls without PCOS was evaluated on Prediction of clinical pregnancy outcome (AUC 0.771, 95% CI 0.617-0.925, p=0.007). Upregulated lncRNA MALAT1 in granulosa cells of patients with PCOS predicted positive clinical pregnancy outcomes with an area under the curve of 0.771.