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September 10, 2025Photodiagnosis and Photodynamic TherapyOpen Access

Two-year treatment outcome of photodynamic therapy combined with anti-vascular endothelial growth factor therapy for pachychoroid neovasculopathy

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Authors

SUSadashige UemuraAMAkiko MikiMKMaya Kishimoto-Kishi

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Overview

Retrospective study shows improved visual acuity and anatomical measures in patients with pachychoroid neovasculopathy, indicating potential effectiveness of combination therapy.

Key Points

  • Combination therapy improved visual acuity significantly over two years, with results maintained until 24 months.
  • Baseline central retinal thickness and subfoveal choroidal thickness decreased significantly after treatment, persisting to the end of the follow-up period.
  • Recurrence occurred in approximately 22.7% of eyes after a mean interval of 8.5 months, highlighting the need for ongoing monitoring.
  • Overall, the combination of photodynamic therapy and anti-VEGF was effective in treating patients with pachychoroid neovasculopathy, suggesting a beneficial approach.

Cite This Study

Uemura et al. (2025) studied this question.

synapsesocial.com/papers/68c1a40954b1d3bfb60de8b8https://doi.org/10.1016/j.pdpdt.2025.104746
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PACHYCHOROID PIGMENT EPITHELIOPATHY2013 · 570 citations
  2. 2Scleral Thickness in Central Serous Chorioretinopathy2020 · 127 citations
  3. 3FOCAL CHOROIDAL EXCAVATION AND ITS ASSOCIATION WITH PACHYCHOROID SPECTRUM DISORDERS2016 · 121 citations
  4. 4Intravitreal aflibercept and ranibizumab for pachychoroid neovasculopathy2019 · 60 citations
  5. 5ONE-YEAR RESULTS OF ADJUNCTIVE PHOTODYNAMIC THERAPY FOR TYPE 1 NEOVASCULARIZATION ASSOCIATED WITH THICKENED CHOROID2015 · 51 citations