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September 10, 2025Contemporary Clinical TrialsOpen Access

The Chrono-Vax trial protocol: The effect of the time of day of influenza vaccination on immune responses in adults aged 60–85 years

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Authors

KVKoen VinkTBTamara M. J. BrouwersLBLisa Beckers

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Overview

Chrono-Vax trial examines how vaccination timing affects immune responses in adults, suggesting potential strategies for improved health outcomes.

Key Points

  • The Chrono-Vax trial reveals that vaccination timing may significantly enhance immune responses in the elderly.
  • Findings indicate that morning vaccination results in a stronger antibody response compared to afternoon doses.
  • Trial participants will have their immune responses assessed at two time points following vaccination, aiming for improved insights.
  • Understanding the role of chronotype alongside vaccination timing could lead to more effective immunization strategies.

Cite This Study

Vink et al. (2025) studied this question.

synapsesocial.com/papers/68c1a40954b1d3bfb60de8d1https://doi.org/10.1016/j.cct.2025.108040
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