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September 10, 2025VaccinesOpen Access

A Narrative Review on How Timing Matters: Circadian and Sleep Influences on Influenza Vaccine Induced Immunity

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Authors

ALAchilleas LivieratosJZJamie M. ZeitzerSTSotirios Tsiodras

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Overview

Narrative review evaluates how vaccination timing and sleep factors influence immune responses.

Key Points

  • Morning vaccination enhances antibody levels, particularly for the A/H1N1 strain in adults aged ≥ 65 years.
  • Short sleep duration before vaccination correlates with reduced antibody responses and increased vulnerability to infections.
  • Findings suggest the need for targeted chrono-immunization strategies to optimize vaccine efficacy in diverse populations.
  • Methodological limitations and inconsistencies in current studies highlight the necessity for further research in this field.

Cite This Study

Livieratos et al. (2025) studied this question.

synapsesocial.com/papers/68c1c62654b1d3bfb60f17a9https://doi.org/10.3390/vaccines13080845
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep2026
  2. 2Morning influenza vaccination elicits superior antigen-specific immune responses in adults aged 60-85 years 22568812026
  3. 3Sleep, Insomnia, and Immune Responses to Influenza Vaccine: State of the Art and Implications for Health Psychology2026
  4. 4The Chrono-Vax trial protocol: The effect of the time of day of influenza vaccination on immune responses in adults aged 60–85 years2025 · 1 citations
  5. 5Seasonality of Influenza and Optimizing Timing of Vaccination: Systematic Review and Meta-Analysis2025 · 2 citations