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September 10, 2025Tropical Journal of Natural Product ResearchOpen Access

In Silico Molecular Docking and Pharmacokinetics Studies on Potential Plasmodium falciparum Casein Kinase-2 Alpha (PfCK-2α) Inhibitors from Alstonia boonei Stem Bark

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Authors

ONO. U. NjokuCCChristian ChibuogwuJOJohn Onyebuchi Ogbodo

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Overview

Computational study reveals potential Foal inhibitors against Plasmodium falciparum, suggesting new antimalarial drugs.

Key Points

  • Selected compounds from Alstonia boonei showed promising antimalarial effects against plasmodium falciparum.
  • Molecular docking demonstrated higher binding affinities of -8.6 to -11.0 kcal/mol compared to artesunate's -7.8 kcal/mol.
  • UPLC-QTOF-MS analysis identified 85 bioactive compounds, with ricinoleic acid and corosolic acid showing high retention times.
  • Further exploration of these compounds is necessary to assess their safety and effectiveness against malaria.

Cite This Study

Njoku et al. (2025) studied this question.

synapsesocial.com/papers/68c1a41654b1d3bfb60df038https://doi.org/10.26538/tjnpr/v9i7.67
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