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September 10, 2025European Heart Journal Supplements

Cardiotoxicity in ibrutinib-treated patients: incidence, management, and impact on treatment outcomes

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Authors

RCR CarvalheiroLML MagalhaesICI Cardoso

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Overview

Retrospective analysis examines cardiotoxicity incidence in ibrutinib patients, suggesting manageable risks related to atrial fibrillation and hypertension.

Key Points

  • Cardiotoxicity was identified in 33% of patients treated with ibrutinib, primarily presenting as atrial fibrillation.
  • Patients experienced various cardiovascular toxicities including hypertension and heart failure, but most were mild and manageable.
  • Significant risk factors for cardiotoxicity included hypertension, smoking, and previous heart failure, impacting patient outcomes.
  • Despite incidents of cardiotoxicity, there were no significant differences in time to suspension of ibrutinib or overall mortality rates.

Cite This Study

Carvalheiro et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5e554b1d3bfb60df22ehttps://doi.org/10.1093/eurheartjsupp/suaf083.176
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The cardiac toll of ibrutinib: exploring atrial fibrillation in treated patients2025
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  4. 4Ibrutinib increases major adverse cardiovascular events through initiation and exacerbation of hypertension2025
  5. 55PSQ-015 Analysis of the occurrence of atrial fibrillation with the administration of ibrutinib: should we be careful with this drug?2024 · 1 citations