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September 10, 2025European Heart Journal Supplements

Ibrutinib increases major adverse cardiovascular events through initiation and exacerbation of hypertension

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Authors

ECElaine ChanKYK H YiuHTHung‐Fat Tse

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Overview

Retrospective cohort study reports increased major adverse cardiovascular events in patients with lymphoma, suggesting hypertension plays a role.

Key Points

  • Ibrutinib treatment was associated with a 30% incidence of major adverse cardiovascular events in patients.
  • Patients experienced a 36% incidence of new-onset hypertension or adjustments in antihypertensive treatment.
  • Logistic regression analysis indicated that new-onset hypertension increased the risk of major adverse cardiovascular events fivefold.
  • The findings highlight a potential cardiotoxic mechanism of ibutinib through hypertension.

Cite This Study

Chan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5e554b1d3bfb60df2c1https://doi.org/10.1093/eurheartjsupp/suaf083.028
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world cardiovascular risks of ibrutinib in chronic lymphocytic leukemia: a retrospective study2025 · 5 citations
  2. 2Cardiotoxicity in ibrutinib-treated patients: incidence, management, and impact on treatment outcomes2025
  3. 3The cardiac toll of ibrutinib: exploring atrial fibrillation in treated patients2025
  4. 4Pre-existing cardiovascular disease increases risk of atrial arrhythmia and mortality in cancer patients treated with Ibrutinib2021 · 19 citations
  5. 5Incidence of cardiovascular and bleeding events and reasons for discontinuation in patients with chronic lymphocytic leukemia treated with ibrutinib—A retrospective analysis on consecutive patients from a well‐defined region2023 · 5 citations