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Evaluation of the systemic immune-inflammation index in relation to histological stages of celiac disease

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Retrospective analysis examines SII's relationship with Marsh classification in celiac disease patients, indicating potential utility as a biomarker.

SII levels showed no significant difference among Marsh groups but increased in Grade 3a patients, suggesting variability in inflammatory response.
Statistical comparisons revealed hemoglobin levels significantly differed across Marsh stages, particularly decreasing in Grade 3c patients.
A retrospective analysis of 115 biopsy-confirmed celiac disease patients was conducted, examining various hematological parameters.
While SII may serve as an inflammatory marker, its limited association with histological stages calls for larger prospective studies.

Kıvrakoğlu et al. (2025) studied this question.

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Retrospective analysis examines SII's relationship with Marsh classification in celiac disease patients, indicating potential utility as a biomarker.