What question did this study set out to answer?

This study aims to assess the diagnostic value of the Systemic Immune-Inflammation Index (SII) and HALP score in predicting histopathological severity in celiac disease.

August 10, 2026Turkish Journal of Internal MedicineOpen Access

Evaluation of the Systemic Immune-Inflammation Index and Hemoglobin Albumin Lymphocyte Platelet Score in Celiac Patients: A Retrospective Single-Center Study

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Authors

AAAycan AcetDumlupinar University SÇSüleyman ÇoşgunUniversity of Health Science CKCengiz KoçakUniversidad CES

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Implication

Retrospective study evaluates SII and HALP to predict histopathological severity in celiac disease, indicating limited diagnostic value.

Key Points

This study aims to assess the diagnostic value of the Systemic Immune-Inflammation Index (SII) and HALP score in predicting histopathological severity in celiac disease.
Retrospective observational study with 112 participants: 51 newly diagnosed celiac disease patients and 61 matched controls.
Diagnosis of celiac disease was based on European Society for the Study of Coeliac Disease criteria.
Comparative analyses, ROC curve assessments, and multivariate logistic regression were performed.
CD patients had lower hemoglobin, ferritin, and total iron-binding capacity compared to controls (p < 0.05).
SII and HALP did not differ significantly between groups, showing limited diagnostic performance (HALP AUC = 0.589; SII AUC = 0.479).
Neither index predicted advanced villous atrophy nor served as an independent predictor in the regression analysis.

Cite This Study

Acet et al. (2026) studied this question.

synapsesocial.com/papers/6a797d3a9c20a9bbd318477d https://doi.org/10.46310/tjim.1976086

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Evaluation of the Systemic Immune-Inflammation Index and Hemoglobin Albumin Lymphocyte Platelet Score in Celiac Patients: A Retrospective Single-Center Study

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Key Points

Cite This Study

Evaluation of the Systemic Immune-Inflammation Index and Hemoglobin Albumin Lymphocyte Platelet Score in Celiac Patients: A Retrospective Single-Center Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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