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September 10, 2025Cancer Research

Abstract P33: High-throughput Transcriptomics Identifies Chemoresistance-associated Gene Expression Signatures in Human Angiosarcoma

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Study reveals significant gene expression patterns associated with chemoresistance in angiosarcoma, indicating potential therapeutic targets.

SPP1 overexpression is identified as a key biomarker associated with chemoresistance in angiosarcoma.
Transcriptomic profiling showed significant gene expression of SPP1, CXCL13, and others, correlating with poor treatment response.
Methods involved high-throughput transcriptomic analysis of 72 angiosarcoma tissue samples to identify candidate biomarkers.
Findings suggest the need for further studies to validate SPP1's role and its underlying mechanisms in chemoresistance.

Khor et al. (2025) studied this question.

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September 10, 2025Cancer Research

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Authors

Study reveals significant gene expression patterns associated with chemoresistance in angiosarcoma, indicating potential therapeutic targets.

SPP1 overexpression is identified as a key biomarker associated with chemoresistance in angiosarcoma.
Transcriptomic profiling showed significant gene expression of SPP1, CXCL13, and others, correlating with poor treatment response.
Methods involved high-throughput transcriptomic analysis of 72 angiosarcoma tissue samples to identify candidate biomarkers.
Findings suggest the need for further studies to validate SPP1's role and its underlying mechanisms in chemoresistance.

Khor et al. (2025) studied this question.

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