Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 9, 2024International Journal of Molecular SciencesOpen Access

High-Throughput Transcriptomics Identifies Chemoresistance-Associated Gene Expression Signatures in Human Angiosarcoma

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Angiosarcomas are aggressive cancers of endothelial origin characterized by chemotherapy resistance and dismal prognosis, creating a need to identify transcriptomic biomarkers of chemoresistance.

Is SPP1 overexpression associated with chemoresistance and poor prognosis in patients with angiosarcoma?

Population

72 cases of Asian angiosarcomas, including 35 treated with palliative chemotherapy

Comparison

Chemoresistant cohort vs responsive disease, and tumor tissues vs adjacent normal compartments

Design

Transcriptomic biomarker study integrating profiling, immunohistochemistry, and cell line assays

Authors

GKGlenys Mai Shia KhorRaffles InstitutionSHSara HaghaniNational Cancer Centre SingaporeTTTiffany Rui En TanNational Cancer Centre Singapore

Discussion

Loading...

Member takes

Implication

SPP1 overexpression may flag chemoresistance risk in angiosarcoma; hypothesis-generating for prospective biomarker validation.

Structured PICO

Is SPP1 overexpression associated with chemoresistance and poor prognosis in patients with angiosarcoma?

P
Population
72 cases of Asian angiosarcomas, including 35 cases treated with palliative chemotherapy, and patient-derived angiosarcoma cell lines MOLAS and ISOHAS
C
Comparator
Chemosensitive cohort and adjacent normal tissue compartments
O
Outcome
Transcriptomic biomarkers of chemoresistance and overall survivalsurrogate

SPP1 overexpression is identified as a potential biomarker for chemoresistance and poor prognosis in Asian patients with angiosarcoma.

Cite This Study

Khor et al. (2024) studied this question.

synapsesocial.com/papers/6a8d09c746b16fbda7daca21https://doi.org/10.3390/ijms251910863
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.1995 · 513 citations
  2. 2Clinical implications of systemic and local immune responses in human angiosarcoma2021 · 15 citations
  3. 3Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers2022 · 41 citations