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September 10, 2025Nature CommunicationsOpen Access

Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger

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Authors

KSKirsty SandsALAditya Kumar LankapalliGLGiulia Lai

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Overview

Observational analysis shows high colonisation rates of escherichia coli with resistance genes in children, indicating serious infection control issues.

Key Points

  • High colonisation rates of bacteria with resistance genes were found in children with severe acute malnutrition.
  • About 76% of children carried bacteria with the bla CTXM-1 gene, while 25% had the bla NDM-5 gene.
  • Over two-thirds of children without carbapenemase genes upon admission became colonised by discharge.
  • Concerns arise regarding antimicrobial resistance transmission in a vulnerable population in need of treatment.

Cite This Study

Sands et al. (2025) studied this question.

synapsesocial.com/papers/68c1a76954b1d3bfb60e04d1https://doi.org/10.1038/s41467-025-61718-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High prevalence of blaNDM gene among a series of carbapenem-resistant Enterobacterales isolates from children less than one year old in Niger2026
  2. 2β-Lactamase and Macrolide Resistance Gene Carriage in <i>Escherichia coli</i> Isolates Among Children Discharged From Inpatient Care in Western Kenya: A Cross-sectional Study2024 · 3 citations
  3. 3Characterization of Antibiotic Resistance and Prevalence of Diarrheagenic &lt;em&gt;E. coli &lt;/em&gt;Strains Isolated from Stool Samples in a Hospital Setting in Mali2025
  4. 4Phenotypic and genomic characterization of NDM-producing <i>Escherichia coli</i> colonizing the pediatric gut in Shenzhen, China2026 · 2 citations
  5. 5Occurrence of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Escherichia coli isolated from childhood diarrhoea in Yaoundé, Cameroon2024