Dynamic culture enhances epithelial differentiation and barrier maturation in porcine organoid models, suggesting effective organ-on-chip applications.
Porcine intestinal organoid-derived monolayers were cultured under static and dynamic conditions. The dynamic system promoted earlier barrier maturation, enhanced epithelial differentiation, and stable permeability, reflecting improved physiological relevance. These findings support organ-on-chip platforms as effective, biomimetic tools for studying post-weaning intestinal function in vitro, reducing reliance on animal models.
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Boix et al. (2025) studied this question.
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