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September 10, 2025Nano Letters

Carrier-Free Nanoadjuvant-Loaded Bilayer Microneedles for Programmed and Individualized Cancer Chemo-Immunotherapy

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Authors

CHChenlu HuangHWHanyong WangXYXinyu Yang

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Overview

This study demonstrates enhanced antitumor immune response using microneedles loaded with chemo drugs and nanoadjuvants in TNBC.

Key Points

  • The biphasic release of doxorubicin and nanoadjuvants effectively suppresses tumor growth, enhancing the immune response.
  • Microneedle patches combined with aPD-1 therapy resulted in pronounced therapeutic responses against triple-negative breast cancer.
  • The release of immunogenic cell death-inducing doxorubicin promotes tumor-associated antigens for personalized nanovaccine generation.
  • This innovative microneedle approach provides a new avenue for advanced synergistic immunotherapy strategies.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c1a77254b1d3bfb60e078chttps://doi.org/10.1021/acs.nanolett.5c02670
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