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Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry

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Retrospective multiple single-case design shows clozapine reduces psychotic aggression in forensic patients, indicating its potential efficacy.

Clozapine treatment effectively reduces psychotic aggression, benefit noted in 4 out of 5 patients.
Aggression was measured using the Brøset Violence Checklist, indicating significant improvements.
The study was conducted in a forensic psychiatry setting, examining clozapine’s impact on aggression specifically.
Findings suggest clozapine may be effective, though impulsive aggression did not show improvement.

Jelle R. Lettinga (2025) studied this question.

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Retrospective multiple single-case design shows clozapine reduces psychotic aggression in forensic patients, indicating its potential efficacy.