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September 10, 2025Microplastics and NanoplasticsOpen Access

Top-down generated micro- and nanoplastics reduce macrophage viability without eliciting a pro-inflammatory response

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Authors

ABAnnemijne E. T. van den BergUtrecht UniversityKAKas J. AdriaansUtrecht UniversityLPLuke A. ParkerNetherlands Organisation for Applied Scientific Research

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Implication

Observational analysis shows fragmented microplastics reduce macrophage viability, suggesting inflammatory responses are not triggered.

Key Points

  • Fragmented microplastics decreased mitochondrial activity in macrophages, indicating potential cytotoxic effects.
  • MNPs did not significantly induce NF-κB activity or cytokine production in human macrophages.
  • Increased lysosomal activity observed suggests macrophages attempt to process microplastics.
  • This research highlights the importance of assessing the health impacts of microplastics in the environment.

Cite This Study

Berg et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e0f9ehttps://doi.org/10.1186/s43591-025-00138-5
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