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February 24, 2026NanoImpactOpen Access

Effects of true to life polyethylene terephthalate and polycaprolactone nanoparticles on macrophages under a repeated exposure mode

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Examines how repeated exposure to nanoplastics affects macrophage responses, suggesting important health implications.

To explore the effects of repeated exposure to polyethylene terephthalate and polycaprolactone nanoparticles on macrophage functionality.
Utilized a repeated exposure scheme for macrophage cells to nanoplastics.
Compared effects of polyethylene terephthalate and polycaprolactone nanoparticles.
Used proteomic and targeted experiments to analyze cellular responses.
Macrophages adapted with lesser proteomic changes under repeated exposure compared to acute exposure.
Pet nanoparticles induced oxidative stress and a pro-inflammatory response in macrophages.
PCL nanoparticles led to decreased macrophage functions, especially in cytokine production.

Collin‐Faure et al. (2026) studied this question.

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