Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025BiologyOpen Access

Zebrafish as a Model Organism for Post-Traumatic Stress Disorder: Insights into Stress Mechanisms and Behavioral Assays

View Full Paper
Ask AI
Bookmark
Share

Authors

ASAlexey SarapultsevMKMaria KomelkovaOLOleg Lookin

Discussion

Loading...

Member takes

Overview

Systematic review clarifies behavioral assays and stress mechanisms in zebrafish for PTSD, suggesting effective strategies.

Key Points

  • Chronic unpredictable stress protocols reliably induced core PTSD-like phenotypes, including anxiety-like behavior.
  • 14-15-day chronic unpredictable stress protocols are highlighted as the gold standard for modeling PTSD in zebrafish.
  • The study emphasizes the significance of standardized behavioral and molecular endpoints for model validation in zebrafish.
  • Future zebrafish-based PTSD research requires protocol harmonization and exploration of individual variability for enhanced results.

Cite This Study

Sarapultsev et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78854b1d3bfb60e15f3https://doi.org/10.3390/biology14080939
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool2024 · 11 citations
  2. 2Divergent neurobehavioral signatures of anxiety and depression: a multilevel comparative analysis in adult zebrafish2026
  3. 3Study on some behavioral and oxidative changes observed in zebrafish exposed to chronic stress2024
  4. 4A Standardized Unpredictable Chronic Stress Protocol for Adult Zebrafish2026
  5. 5Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives2025