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November 14, 2025LifeOpen Access

Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives

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Authors

LPLidia PanseraKMKamel MhalhelMCMauro Cavallaro

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Overview

This review highlights the role of zebrafish in understanding CNS disorders and developing therapeutic strategies, indicating their significance in research.

Key Points

  • The aim is to explore the potential of zebrafish as models for studying central nervous system disorders and therapeutic strategies.
  • Review of current advances in zebrafish models
  • Analysis of genetic alterations and environmental exposures
  • Evaluation of pathophysiological processes in CNS disorders
  • Assessment of therapeutic strategies using zebrafish
  • Zebrafish show significant neuroanatomical homology with humans
  • They have regenerative abilities in the CNS
  • Research indicates potential for zebrafish in screening therapeutics for CNS disorders

Cite This Study

Pansera et al. (2025) studied this question.

synapsesocial.com/papers/692519a2c0ce034ddc353be6https://doi.org/10.3390/life15111751
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  4. 4Zebrafish (Danio rerio) as a Model for Neurodegenerative Disease Research: Mechanisms, Biomarkers, and Translational Promise2026
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