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April 21, 2026CNS & Neurological Disorders - Drug Targets

Zebrafish (Danio rerio) as a Model for Neurodegenerative Disease Research: Mechanisms, Biomarkers, and Translational Promise

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Authors

NKN Toushif KhanGDGaurav Doshi

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Overview

This review shows how zebrafish models advance neurodegenerative disease research, indicating their potential for therapeutic innovations.

Key Points

  • To explore the applicability of zebrafish as models for studying mechanisms and biomarkers of neurodegenerative diseases.
  • Reviewed anatomical and neurochemical similarities between zebrafish and humans.
  • Analyzed various neurodegenerative disease models established using zebrafish.
  • Assessed the role of zebrafish in drug discovery and mechanistic studies.
  • Zebrafish models effectively mimic neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's.
  • The anatomical and neurochemical properties of zebrafish support their use in studying human neurological disorders.
  • Zebrafish provide a scalable and ethical platform for early-stage drug screening and research.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/69e713decb99343efc98d3adhttps://doi.org/10.2174/0118715273442688260330060220
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery2018 · 236 citations
  2. 2Genetic Approaches in Zebrafish Neurology: Genetic, Drug and TherapyInsights2026
  3. 3Zebrafish as a Versatile Screening Model for Neurological Diseases: Insights Into Biology, Drug Delivery and Therapeutic Discovery.2026 · 2 citations
  4. 4Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives2025
  5. 5Zebrafish as a Model Organism to Study Neurotoxicity: A Potential Tool for Neuroprotective Drug Discovery2026