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February 27, 2026

Zebrafish as a Versatile Screening Model for Neurological Diseases: Insights Into Biology, Drug Delivery and Therapeutic Discovery.

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Authors

SVS. H. VyavahareJehangir Clinical development CentreAPAtharva PawarJehangir Clinical development CentreSSShafiya A SayyedJehangir Clinical development Centre

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Overview

Review highlights zebrafish's role in modeling neurological disorders and drug discovery, indicating significant advantages for research.

Key Points

  • The review aims to summarize the use of zebrafish in studying neurological diseases and their potential for drug discovery.
  • Overview of anatomical and neurochemical features of zebrafish nervous system
  • Discussion on various drug administration strategies, including bath immersion and microinjection
  • Exploration of zebrafish models for major neurological disorders
  • Analysis of applications in drug screening and evaluation of neuroprotective compounds
  • Examination of future perspectives on genetic engineering and targeted delivery systems
  • Zebrafish exhibit genetic similarities to humans, aiding in neurological research
  • High-throughput behavioral and pharmacological investigations are feasible using zebrafish
  • Various innovative drug delivery methods enhance therapeutic assessment
  • Zebrafish models demonstrate unique advantages over traditional mammalian systems for drug discovery
  • Potential applications in repurposing therapeutics and advancing translational neuroscience are promising.

Cite This Study

Vyavahare et al. (2026) studied this question.

synapsesocial.com/papers/69a1351ded1d949a99abeb79https://doi.org/10.1002/jbt.70750
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Zebrafish (Danio rerio) as a Model for Neurodegenerative Disease Research: Mechanisms, Biomarkers, and Translational Promise2026
  2. 2Genetic Approaches in Zebrafish Neurology: Genetic, Drug and TherapyInsights2026
  3. 3Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery2018 · 236 citations
  4. 4Advancing Neuroscience through Zebrafish: Challenges, Innovations, and Future Directions2024 · 1 citations
  5. 5Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives2025