Access to chiral α-methyl-α-aryl carboxylic acids via phosphoric acid-catalyzed kinetic resolution of biaryl oxazepines

Guo Dai; Yifei Ma; Wenyue Tan; Ting Tu; Bowen Zhu; Zhikang Wei; Liejin Zhou; Shi‐Chao Ren; Xing Yang

doi:10.1039/d5qo00953g

January 1, 2025Organic Chemistry Frontiers

Access to chiral α-methyl-α-aryl carboxylic acids via phosphoric acid-catalyzed kinetic resolution of biaryl oxazepines

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Key Points

The methodology enables selective transformation of racemic biaryl oxazepines into chiral products, enhancing synthetic utility.
High enantioselectivities were achieved, demonstrating the effectiveness of phosphoric acid as a catalyst in this kinetic resolution process.
This innovative approach could significantly benefit the production of compounds with chiral centers in pharmaceutical applications.
Enhancements in chiral synthesis techniques point to advancements in asymmetric catalysis, broadening future research opportunities.

Implication

This method achieves high enantioselectivities in converting racemic biaryl oxazepines, suggesting practical applications in chemical synthesis.

Abstract

A chiral phosphoric acid-catalyzed kinetic resolution of racemic biaryl oxazepines with alcohols was developed, which afforded biaryl oxazepines and imidates bearing a chiral center in high enantioselectivities.

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Cite This Study

Dai et al. (2025) studied this question.

synapsesocial.com/papers/68c1a8f654b1d3bfb60e18a4 https://doi.org/10.1039/d5qo00953g

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Access to chiral α-methyl-α-aryl carboxylic acids via phosphoric acid-catalyzed kinetic resolution of biaryl oxazepines

Key Points

Implication

Abstract

Discussion

Cite This Study

Access to chiral α-methyl-α-aryl carboxylic acids via phosphoric acid-catalyzed kinetic resolution of biaryl oxazepines

Key Points

Implication

Abstract

Discussion

Cite This Study

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