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September 10, 2025Open Veterinary JournalOpen Access

Insulin Like Growth Factor 1 and Estrogen from Cumulus cell culture increase the success of in vitro fertilization in cattle

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Authors

SMSri MulyatiIMImam MustofaPSPudji Srianto

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Overview

Research shows that IGF-1 and estrogen from cumulus cell culture improve embryo development and reduce apoptosis in IVF, indicating enhanced reproductive outcomes.

Key Points

  • Supplying IGF-1 and estrogen from cumulus cells significantly improves IVF success rates in cattle.
  • Embryo cleavage rates with supplementation reached 53.61%, compared to 27.48% without it, highlighting its impact.
  • The study utilized TCM 199 supplemented media and a specialized binding technique for effective hormonal regulation.
  • Results indicate a marked reduction in apoptosis from 70.58% to 31.01%, suggesting improved embryo viability.

Cite This Study

Mulyati et al. (2025) studied this question.

synapsesocial.com/papers/68c1a8fe54b1d3bfb60e1a89https://doi.org/10.5455/ovj.2025.v15.i7.13
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gene expression levels in cumulus cells are correlated with developmental competence of bovine oocytes.2024 · 10 citations
  2. 2<b>Potential of growth factors and steroid hormones from cell cultures to improve <i>in vitro</i> fertilization in bovine</b><b></b>2025 · 1 citations
  3. 3Insulin-like Growth Factor-1 Supplementation and Early Embryonic Developmental Competence of Immature Cattle Oocytes2025 · 1 citations
  4. 4Effect of Different Growth Factors on in vitro Developmental Competence and Quality of Cattle Oocytes2024
  5. 5Effect of Epidermal Growth Factor on In Vitro Maturation, Fertilization and Early Embryonic Development of Cattle Oocytes2024