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September 10, 2025International Journal of Child Health and Nutrition

Serum 25-Hydroxyvitamin D Concentration Status and Neonatal Immune Function: New Perspectives in Anticipating Late Onset Sepsis among Preterm Neonates at Tertiary Care Centres (A Prospective Study)

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Authors

MEMohammed Younis Mohammed ElbeheryNANaguib Abdellatif Abdelfattah AbdellatifMAMohamed Morsi M. Ahmed

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Overview

This prospective study investigates vitamin D levels in cord blood, revealing no correlation with neonatal sepsis in preterm infants.

Key Points

  • Neonatal sepsis incidence remains unchanged despite varying vitamin D levels among preterm infants, indicating a complex relationship.
  • In this study, vitamin D deficiency defined as less than 15 ng/mL showed no significant link with neonatal sepsis in 150 preterm infants.
  • This prospective study enrolled 150 preterm neonates, assessing vitamin D status against sepsis markers across two tertiary care centres.
  • The findings highlight the need for larger studies to validate these outcomes, while suggesting existing concerns about vitamin D's role may need reevaluation.

Cite This Study

Elbehery et al. (2025) studied this question.

synapsesocial.com/papers/68c1a8fe54b1d3bfb60e1cbehttps://doi.org/10.6000/1929-4247.2025.14.03.9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Relation Between 25-Hydroxyvitamin D Levels and Sepsis in Neonatal Intensive Care Unit Infants: A Comprehensive Systematic Review2025
  2. 2Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study2024 · 3 citations
  3. 3Role of Vitamin D and Parathyroid Hormone Levels in Prediction of Late Onset Sepsis among Preterm Infants: A Prospective Cohort study2024
  4. 4Early neonatal vitamin D status and neonatal sepsis: a retrospective cohort study complemented by Mendelian randomization2026
  5. 5A Prospective Cross-Sectional Study on the Vitamin D Status of Neonates and the Impact of Neonates’ Standard Vitamin D Supplementation on Neonatal Morbidities2024 · 4 citations