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September 17, 2025The International Journal of Medical Science and Health ResearchOpen Access

The Relation Between 25-Hydroxyvitamin D Levels and Sepsis in Neonatal Intensive Care Unit Infants: A Comprehensive Systematic Review

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Authors

NPNurul PurnamasariRARirin Azhari

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Overview

Systematic review finds lower 25-hydroxyvitamin D levels are linked to higher risk of neonatal sepsis, suggesting vitamin D may act as a modifiable risk factor.

Key Points

  • Lower 25-hydroxyvitamin D levels significantly increase the risk of neonatal sepsis.
  • Neonates born to vitamin D-deficient mothers had a notably higher incidence of infections.
  • Vitamin D deficiency is associated with increased sepsis severity and longer NICU stays.
  • Optimizing vitamin D levels could serve as a preventive strategy for neonatal sepsis.

Cite This Study

Purnamasari et al. (2025) studied this question.

synapsesocial.com/papers/68d461b631b076d99fa6058chttps://doi.org/10.70070/zhjype47
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin D and Neonatal Sepsis: Current Evidence, Biological Mechanisms, and Future Directions—A Scoping Review2026
  2. 2Early neonatal vitamin D status and neonatal sepsis: a retrospective cohort study complemented by Mendelian randomization2026
  3. 3Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study2024 · 3 citations
  4. 4Serum 25-Hydroxyvitamin D Concentration Status and Neonatal Immune Function: New Perspectives in Anticipating Late Onset Sepsis among Preterm Neonates at Tertiary Care Centres (A Prospective Study)2025
  5. 5Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis2025 · 3 citations