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August 5, 2026NutrientsOpen Access

Vitamin D and Neonatal Sepsis: Current Evidence, Biological Mechanisms, and Future Directions—A Scoping Review

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Authors

DPDominika PawRBRenata BokiniecKWKrzysztof Włodarczyk

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Overview

Scoping review outlines vitamin D's impact on neonatal sepsis outcomes, highlighting gaps in existing research.

Key Points

  • This review aims to systematically outline the role of vitamin D in neonatal sepsis, including its effects on incidence, severity, and treatment outcomes.
  • Conducted a literature search in MEDLINE and EMBASE databases with no date limit.
  • Included experimental, observational, and descriptive studies addressing vitamin D status and supplementation in neonatal sepsis.
  • Followed PRISMA Extension for Scoping Reviews guidelines.
  • Vitamin D deficiency is globally prevalent among neonates and correlates with increased risk or severity of sepsis.
  • Forty-five studies were analyzed, most being observational, primarily from South Asia and the Middle East.
  • Methodological variability limited cross-study comparisons, highlighting the need for standardized research.

Cite This Study

Paw et al. (2026) studied this question.

synapsesocial.com/papers/6a72e84e226790f3706580aahttps://doi.org/10.3390/nu18152517
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin D Status and Sepsis Outcomes: A PRISMA-Compliant Umbrella Review and Meta-Analysis2026 · 2 citations
  2. 2Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response2006 · 3,965 citations
  3. 3Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants2017 · 31 citations
  4. 4Vitamin D deficiency in critically ill children: a systematic review and meta-analysis2017 · 102 citations
  5. 5Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors2019 · 15 citations