What question did this study set out to answer?

This research aims to analyze the relationship between vitamin D deficiency, genetic factors, and sepsis outcomes.

March 12, 2026NutrientsOpen Access

Vitamin D Status and Sepsis Outcomes: A PRISMA-Compliant Umbrella Review and Meta-Analysis

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This umbrella review examines vitamin D deficiency and its impact on sepsis outcomes, highlighting treatment implications.

This research aims to analyze the relationship between vitamin D deficiency, genetic factors, and sepsis outcomes.
Conducted an umbrella review of systematic reviews and meta-analyses from 2014 to 2025.
Included studies on adult, pediatric, and neonatal populations related to sepsis outcomes.
Searched databases like PubMed and journal archives for relevant reviews and meta-analyses.
Utilized qualitative synthesis, forest plots, and funnel plots to summarize evidence.
Identified 19 systematic reviews and meta-analyses involving over 300 primary studies.
Vitamin D deficiency linked to increased sepsis risk, higher mortality, and greater disease severity.
Stronger associations found in children and neonates, showing higher scores for illness severity.
VDR gene polymorphisms associated with increased susceptibility to sepsis.
Vitamin D supplementation did not consistently reduce sepsis risk or mortality.

Castro-Luna et al. (2026) studied this question.

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