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September 10, 2025VirusesOpen Access

Chimeric Vesicular Stomatitis Virus Bearing Western Equine Encephalitis Virus Envelope Proteins E2-E1 Is a Suitable Surrogate for Western Equine Encephalitis Virus in a Plaque Reduction Neutralization Test

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Chimeric VSV/WEEV serves as an effective alternative for western equine encephalitis virus in diagnostics.
PRNT90 and IC90 values for VSV/WEEV closely matched those of parental WEEV using animal sera.
The novel virus chimera significantly reduces assay readout time by around 8 hours compared to parental WEEV.
Using VSV/WEEV allows for safer testing in BSL-2 facilities, minimizing risks for personnel.

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Chimeric vesicular stomatitis virus shows comparable results in plaque reduction neutralization tests, expanding serodiagnosis options.

Miazgowicz et al. (2025) studied this question.

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