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The aim was to develop a sensitive and specific serological method to detect Venezuelan equine encephalitis virus (VEEV) antibodies in horses.

June 12, 2026PLoS ONEOpen Access

Development of an indirect ELISA for the detection of venezuelan equine encephalitis virus specific antibodies in horses

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The aim was to develop a sensitive and specific serological method to detect Venezuelan equine encephalitis virus (VEEV) antibodies in horses.
Developed an in-house indirect enzyme-linked immunosorbent assay (ELISA) based on the E2 glycoprotein of VEEV.
Evaluated using 469 samples from various equine populations, including non-infected and naturally infected horses.
Assessed sensitivity and specificity of the assay.
The ELISA showed a sensitivity of 97.3% and specificity of 93.8%.
Demonstrated robust diagnostic performance as an alternative to traditional virus neutralization methods.
Provides a viable option for sero-epidemiological studies on VEEV distribution and monitoring potential virus introduction.

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Randomized trial demonstrates effective detection of Venezuelan equine encephalitis virus in horses, indicating a valuable diagnostic tool.

Chevrier et al. (2026) studied this question.

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Randomized trial demonstrates effective detection of Venezuelan equine encephalitis virus in horses, indicating a valuable diagnostic tool.