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September 10, 2025

Solid Dispersion-Based Approaches for Improving Oral Bioavailability: Current Progress and Future Perspectives

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Authors

GRGayathri RajaramTamil Nadu Dr. M.G.R. Medical UniversityCKC. KrishnanOccidental Petroleum (United States)MSMonika SekarSRM Institute of Science and Technology

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Overview

This review discusses solid dispersion technology's role in enhancing oral bioavailability of poorly soluble APIs, highlighting recent advancements and implications.

Key Points

  • Solid dispersion technology improves oral bioavailability of poorly soluble active pharmaceutical ingredients, enhancing therapeutic effects.
  • Recent advancements include novel carriers and techniques like hot-melt extrusion, significantly boosting dissolution rates.
  • Analytical methods such as DSC and TMDSC aid in understanding the mechanisms of improved drug absorption through solid dispersions.
  • Solid dispersions present a flexible and commercially promising approach for formulating stable amorphous drug systems.

Cite This Study

Rajaram et al. (2025) studied this question.

synapsesocial.com/papers/68c1aab854b1d3bfb60e2bcbhttps://doi.org/10.38124/ijisrt/25jul1184
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