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September 10, 2025Cell ReportsOpen Access

Single-cell multiomics reveals the oscillatory dynamics of mRNA metabolism and chromatin accessibility during the cell cycle

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Authors

MNMaulik K. NariyaDSDavid Santiago‐AlgarraOTOlivier Tassy

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Overview

Single-cell multiomics reveals oscillatory dynamics of mRNA metabolism and chromatin during the cell cycle, indicating crucial regulatory roles.

Key Points

  • Both transcriptional and post-transcriptional processes display distinct oscillatory waves during the cell cycle.
  • The study identified critical regulators that influence mRNA accumulation and chromatin accessibility.
  • Single-cell multiome sequencing combined with modeling techniques provided a high-resolution map of RNA metabolism.
  • Post-transcriptional regulation plays a significant role in gene expression control in proliferating cells.

Cite This Study

Nariya et al. (2025) studied this question.

synapsesocial.com/papers/68c1aacc54b1d3bfb60e35f6https://doi.org/10.1016/j.celrep.2025.116089
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