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September 10, 2025The Journal of the Acoustical Society of America

Bubble-enhanced ultrasound and radiation in healthy brain tissue: Exploring the parameter space for a novel neurosurgical tool

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Authors

SFStecia‐Marie FletcherBrigham and Women's HospitalTOTiago OliveiraBrigham and Women's HospitalMLMichael LavelleBrigham and Women's Hospital

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Implication

Observational analysis combined microbubble-mediated focused ultrasound and radiation therapy in healthy brain tissue, suggesting a novel neurosurgical method.

Key Points

  • Combined microbubble-mediated focused ultrasound and radiation therapy induced targeted ablation in healthy brain tissue.
  • Lesions measuring approximately 3 × 3 mm2 were noted for radiation doses of 12 Gy and above, confirming effective treatment.
  • The method involved targeting the striatum in healthy rats using pulsed focused ultrasound and monitoring with MRI.
  • Findings indicate that edema post-ultrasound may predict successful outcomes, necessitating further exploration of treatment parameters.

Cite This Study

Fletcher et al. (2025) studied this question.

synapsesocial.com/papers/68c1abf954b1d3bfb60e4242https://doi.org/10.1121/10.0038143
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