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September 10, 2025Endocrine Metabolic & Immune Disorders - Drug Targets

Diagnostic Biomarkers and Targeted Drug Prediction for Acute Kidney Injury: A Computational Approach

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Authors

LZLiuyin ZhouChongqing Emergency Medical CenterLPLiping PanApple (Israel)JGJiayang GaoShanghai Ocean University

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Overview

This analysis identifies predictive biomarkers in acute kidney injury, suggesting novel therapeutic targets.

Key Points

  • Four diagnostic biomarkers were identified with AUC values greater than 0.8, indicating strong predictive performance.
  • A total of 498 key modular genes related to acute kidney injury were screened, alongside 88 differentially expressed genes.
  • Integrative analysis was conducted using machine learning techniques and molecular docking to predict drug interactions.
  • These findings could lead to improved early diagnosis and targeted treatment strategies for acute kidney injury.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5554b1d3bfb60e506dhttps://doi.org/10.2174/0118715303417142250724042300
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unraveling the molecular landscape and therapeutic strategies for acute kidney injury: insights from transcriptomics, network pharmacology, virtual screening, and in vitro experiments2026 · 2 citations
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  3. 3Biomarkers in pursuit of precision medicine for acute kidney injury: hard to get rid of customs2024 · 5 citations
  4. 4Identification and Validation of Potential Biomarkers and Their Functions in Acute Kidney Injury2020 · 43 citations
  5. 5Triple Biomarkers in the Early Diagnosis of Acute Kidney Injury: a Comprehensive Review2025