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September 10, 2025Infectious Disorders - Drug Targets

The Counter-Regulatory Renin-Angiotensin System: A Surprising Ally in the Field of COVID-19

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Authors

MPMariali Palacios-CruzUniversidad Libre de ColombiaJCJairo Castellar-LópezUniversity of La GuajiraJPJuan Manuel PreteltUniversidad Libre de Colombia

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Implication

This review examines the interaction between SARS-CoV-2 and the renin-angiotensin system, highlighting ACE2’s role and treatment potential.

Key Points

  • Ang-(1-7) and Ang-(1-9) show protective cardiovascular effects against COVID-19 complications, preventing heart damage.
  • Research highlights ACE2's dual role in viral entry and protection; its relationship with COVID-19 is crucial.
  • Systematic review was conducted on peer-reviewed studies linking SARS-CoV-2 and RAS components like ACE2, Ang-(1-7), and Ang-(1-9).
  • More clinical evidence is needed to confirm the therapeutic potential of Ang-(1-7) and Ang-(1-9) in COVID-19 treatment.

Cite This Study

Palacios-Cruz et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5554b1d3bfb60e5070https://doi.org/10.2174/0118715265352715250717101135
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Human Homolog of Angiotensin-converting Enzyme2000 · 2,047 citations
  2. 2Renin–Angiotensin–Aldosterone System and Immunomodulation: A State-of-the-Art Review2021 · 97 citations
  3. 3ACE2, a multifunctional protein – from cardiovascular regulation to COVID-192020 · 14 citations
  4. 4Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation2020 · 124 citations
  5. 5Favorable Vascular Actions of Angiotensin-(1–7) in Human Obesity2017 · 58 citations