Three-Component Reaction of Isocyanates and 3-Aminoacrylates: Selective Synthesis of N-2-Aryl-1,2,3-Triazoles and Hydrazones

Jie Huang; Weijie Ren; Jiehao Chen; Xiangrong Xiao; Jiaqi Li; Dongyi Wang; Wenyuan Yu; Juan Zhao; Xiuwen Chen; Zhongzhi Zhu

doi:10.1039/d5cc03602j

January 1, 2025Chemical Communications

Three-Component Reaction of Isocyanates and 3-Aminoacrylates: Selective Synthesis of N-2-Aryl-1,2,3-Triazoles and Hydrazones

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Key Points

Selective synthesis of N-2-aryl 1,2,3-triazoles was achieved through a three-component reaction.
The reaction involves nitrogen sources, 3-aminoacrylates, and isocyanates, demonstrating significant versatility.
Condition-controlled methods using (NH4)2Ce(NO3)6 led to the formation of polyfunctionalized hydrazones.
This work highlights new pathways for synthesizing complex nitrogen-containing compounds.

Implication

Novel three-component reaction enables selective synthesis of N-2-aryl 1,2,3-triazoles and hydrazones, indicating versatile applications.

Abstract

This study presents a novel three-component reaction of nitrogen sources, 3-aminoacrylates and isocyanates, enabling the condition-controlled selective synthesis of N-2-aryl 1,2,3-triazoles and polyfunctionalized hydrazones. In this transformation, (NH4)2Ce(NO3)6 and TBN,...

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5554b1d3bfb60e53dc https://doi.org/10.1039/d5cc03602j

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Three-Component Reaction of Isocyanates and 3-Aminoacrylates: Selective Synthesis of N-2-Aryl-1,2,3-Triazoles and Hydrazones

Key Points

Implication

Abstract

Discussion

Cite This Study

Three-Component Reaction of Isocyanates and 3-Aminoacrylates: Selective Synthesis of N-2-Aryl-1,2,3-Triazoles and Hydrazones

Key Points

Implication

Abstract

Discussion

Cite This Study

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