Clinical view on pathomorphological risk factors after initial enucleation of the eye for retinoblastoma. Literature review

Retinoblastoma (RB) is the most common malignant tumor of the eye found in pediatric practice. Currently, in developed countries, the overall survival rate is approaching 100 % with a high rate of eye preservation up to 90 %, but such a treatment method as enucleation remains relevant today. The study of prognostic morphological factors in eyes removed after enucleation has been the subject of study for several decades in order to optimize adjuvant therapy. On the one hand, to intensify treatment to prevent relapse of RB, on the other hand, to refuse chemotherapy to avoid “overtreatment” of the patient. Our article presents an analysis of the experience of different countries in determining morphological risk factors that influence the appointment of adjuvant chemotherapy after primary enucleation.