Morphological features of retinoblastoma – primary and secondary eye changes. Practical issues

A retrospective analysis of histological studies of 60 enucleated eyes with a clinical diagnosis of the retinoblastoma (RB) was carried out. The article presents a summary data on changes in the retina, choroid, iris, sclera, optic nerve and other structures of the eye affected by the tumor, signs of the RB aggression, and ways of extrabulbar spread. A standardized protocol for morphological examination of the eyes with RB was used in the study. Attention was paid to the histological signs of therapeutic pathomorphosis of the RB, secondary glaucoma and subatrophy of the eyeball. The article also contains recommendations about macro- and microscopic examination of the eyeball with intraocular tumor – RB.