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September 10, 2025BiomedicinesOpen Access

Clinical and Cognitive Improvement Following Treatment with a Hemp-Derived, Full-Spectrum, High-Cannabidiol Product in Patients with Anxiety: An Open-Label Pilot Study

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Authors

RSRosemary T. SmithMDMary Kathryn DahlgrenKSKelly A. Sagar

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Overview

Open-label trial shows reductions in anxiety and improvements in quality of life for patients, suggesting potential benefits of hemp-derived CBD.

Key Points

  • Patients reported significant reductions in anxiety symptoms over time, indicating potential effectiveness of the treatment.
  • Clinical assessments showed concurrent improvements in mood, sleep, and quality of life domains alongside cognitive performance.
  • The open-label pilot clinical trial involved 12 patients, assessing the effects of CBD over six weeks with self-administered treatment.
  • Findings suggest promising efficacy and tolerability, calling for further rigorous studies to validate results in larger populations.

Cite This Study

Smith et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad6354b1d3bfb60e5837https://doi.org/10.3390/biomedicines13081874
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term treatment for unspecified anxiety disorders with cannabidiol (CBD): A retrospective case series from real-world evidence (RWE) in Colombia2024 · 1 citations
  2. 2The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical trial2024 · 8 citations
  3. 3Efficacy and Safety of Cannabidiol for Anxiety: A Bibliometric Analysis and Systematic Review2025
  4. 4A pilot study to evaluate the safety and efficacy of ‘Canna Relief’ Stress Management Oil after oral consumption in patients with Stress and Mild to Moderate Anxiety Disorder2024
  5. 5Acute Effects of Cannabigerol on Anxiety, Stress, and Mood: A Double-Blind, Placebo- Controlled, Crossover, Field Trial2024