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September 10, 2025Frontiers in ImmunologyOpen Access

Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential

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Authors

KZKai ZhouJZJiaxiang ZhouXLXuanxiang Luo

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Overview

Analysis highlights diagnostic potential of hypoxia-related genes and immune infiltration in intervertebral disc degeneration.

Key Points

  • Hypoxia-related genes significantly impact intervertebral disc degeneration, revealing two molecular subtypes.
  • Nine hypoxia-related differentially expressed genes, including RCOR2 and STAT3, showcased high diagnostic efficacy.
  • Functional enrichment analysis indicates the involvement of key pathways like TP53 transcription and MAPK signaling.
  • Distinct immune infiltration patterns were correlated with identified hypoxia-related genes across IDD subtypes.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad6a54b1d3bfb60e5ea2https://doi.org/10.3389/fimmu.2025.1606905
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Also Consider

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  1. 1Identification of core genes in intervertebral disc degeneration using bioinformatics and machine learning algorithms2024 · 14 citations
  2. 2Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics2025
  3. 3Unveiling key genes for intervertebral disc degeneration prediction and potential drug discovery2025
  4. 4Identification of Biomarkers in Intervertebral Disc Degeneration Using Bioinformatics and Machine Learning Algorithms2024
  5. 5Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis2026