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September 10, 2025Journal of CancerOpen Access

Integrative Analysis of Histone Deacetylases Reveals the Potential Role and Prognostic Value of HDAC7 in Hepatocellular Carcinoma

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Authors

CYChangjiang YangZYZhenze YuRWRanran Wang

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Overview

Analysis demonstrates HDAC7's differential expression in hepatocellular carcinoma, indicating its prognostic value and involvement in epigenetic regulation.

Key Points

  • HDAC7 expression levels significantly correlate with prognosis and pathological staging in hepatocellular carcinoma.
  • Differential expression patterns of histone deacetylases were observed in clinical samples, showcasing their role in cancer progression.
  • Functional enrichment analyses suggest HDAC7 may act as an oncogene by modulating expression in tumorigenic pathways.
  • Immune cell infiltration analysis highlights the interaction between HDAC7 expression and various immune cell types.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c1ae6654b1d3bfb60e62b4https://doi.org/10.7150/jca.112983
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HDAC7: a promising target in cancer2024 · 15 citations
  2. 2Epigenetic Regulation Through Histone Deacetylation: Implications and Therapeutic Potential in Hepatocellular Carcinoma2025 · 16 citations
  3. 3Integrative Bioinformatic Characterization of the HDAC6-Driven Cytoskeleton–Wnt Signaling Interface in Hepatocellular Carcinoma: Implications for Immune Modulation and Therapeutic Targeting2026 · 1 citations
  4. 4Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma.2021 · 7 citations
  5. 5Prognosis and immunological characteristics of HDAC family in pan-cancer through integrative multi-omic analysis2024 · 3 citations